Salt-induced guest relocation from a macrocyclic cavity into a biomolecular pocket: interplay between cucurbit[7]uril and albumin.

Cucurbituril Receptor: a Versatile Host for Modulating the Molecular Properties of Chromophoric Dyes

The molecular association through host-guest interaction of chromophoric dyes having technological and biological importance have been investigated with a macrocyclic receptor, cucurbit[7]uril (CB7). Exploiting host-guest (CB7rhodamine 6G) interaction, the construction of a highly efficient “water-based supramolecular dye laser” has been demonstrated. The CB7 imposed modulation of the protonati...

Cucurbit[7]uril assisted ultraviolet to visible fluorescence switch of a heart medicine.

Host-guest interactions between cucurbit[7]uril (CB7) and a cardiotonic drug, milrinone, have been explored using steady state and pico-second time-resolved techniques. A novel fluorescence switch from ultraviolet (UV) to visible (cyan) is observed as a consequence of upward pKa shift of the drug inside the nano-cavity of cucurbit[7]uril.

Deciphering the specific high-affinity binding of cucurbit[7]uril to amino acids in water.

This work presents a systematic study on the host-guest interactions between the macrocyclic host molecule cucurbit[7]uril (CB[7]) and amino acids (AAs) including three basic AAs (Lys, Arg, and His) and three aromatic AAs (Phe, Tyr, and Trp) to elucidate the origin of the high selectivity of CB[7] toward AA residues in proteins. Complex formation between CB[7] and each AA was examined in soluti...

Host-guest complexations of local anaesthetics by cucurbit[7]uril in aqueous solution.

The cucurbit[7]uril (CB[7]) host molecule forms very stable host-guest complexes with the local anaesthetics procaine (K(CB[7]) = (3.5 +/- 0.7) x 10(4) dm(3) mol(-1)), tetracaine (K(CB[7]) = (1.5 +/- 0.4) x 10(4) dm(3) mol(-1)), procainamide (K(CB[7]) = (7.8 +/- 1.6) x 10(4) dm(3) mol(-1)), dibucaine (K(CB[7]) = (1.8 +/- 0.4) x 10(5) dm(3) mol(-1)) and prilocaine (K(CB[7]) = (2.6 +/- 0.6) x 10(...

Cucurbit[7]uril: a Simple Macrocyclic, pH-triggered Hydrogelator Exhibiting Unprecedented Guest-Induced Stimuli-Responsive Behavior**